| Registro completo |
| Provedor de dados: |
Plantas Medicinales
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| País: |
Cuba
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| Título: |
Achyrocline satureioides (Lam.) DC. (marcela) reduces brain damage in permanent focal ischemia in rats
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| Autores: |
Rivera Megret,Felicia
Tejera Correa,Dario
Abin Carriquiri,Juan Andrés
Prunell dos Santos,Giselle
Martínez Busi,Marcela
Dajas Méndez,Federico
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| Data: |
2013-09-01
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| Ano: |
2013
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| Palavras-chave: |
Achyroclines satureioides
Quercetin
Permanent focal ischemia
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| Resumo: |
Introduction: Achyrocline satureioides is a plant which has been widely used in popular medicine and experimental studies confirm its antioxidant and anti-inflammatory effects, attributable to the presence of flavonoids, mainly quercetin. Objectives: to evaluate the neuroprotective effects of a chronic oral pre-administration to rats with an Achyrocline satureioides decoction (2 %). Methods: for decoction, dried flowers of Achyrocline satureioides were used. The consumption of food and AS decoction/water of the rats was evaluated daily and weight gain weekly; quercetin content in the decoction and in the plasma of the rats was evaluated by high performance liquid chromatography. The cerebral damage was assessed with a tetrazolium salt (TTC) and a behavioral test was performed previously. Nissl staining and Fluoro-Jade histochemistry were used. Results: the pre-treatment with Achyrocline satureioides in all groups reverted the functional deficit and, during 21 days, the infarction volume also decreased significantly. Nissl staining showed a higher percentage of preserved neuronal population and the Fluoro-Jade showed a decreased of the neurons in degeneration. Conclusions: the quercetin levels in the decoction and plasma of rats could explain the preventive benefits of Achyrocline satureioides due to the antioxidant and anti-inflammatory properties described for this flavonoid.
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| Tipo: |
Journal article
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| Idioma: |
Inglês
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| Identificador: |
http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962013000300011
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| Editor: |
ECIMED
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| Formato: |
text/html
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| Fonte: |
Revista Cubana de Plantas Medicinales v.18 n.3 2013
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